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KMID : 0376419960200010001
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Chonbuk University Medical Journal
1996 Volume.20 No. 1 p.1 ~ p.10
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Expression of p53 Protein in Colorectal Carcinoma and Adenoma
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김정길
이호/정명자/최삼임/이동근
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Abstract
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The present study was performed to determine whether the grade of differentiation of colorectal adenocarcinoma and the degree of atypia accompanied with adenoma can be related to different genotypes of these tumors. Paraffin section of 48 human
colorectal adenoma and 61 adenocarcinoma were examined for the overexpression of p53 oncoprotein with the avidin-biotin peroxidase complex staining procedure.
@ES The obtained results were as follows:
@EN 1. All the adenomas showed uniformly negative staining.
2. Nine of the 16 well differentiated adenocarcinoma (56%), twelve of the 24 moderately differentiated adenocarcinoma(50%), and eleven of the 21 poorly differentiated adenocarcinoma(52%) exihibited p53 protein expression. So the percentage of
positive
did not correlate with the grade of differentiation.
3. The pattern of p53 staining varied from the cases that nearly all the nuclei of neoplastic cells were stained to the cases that a few scattered nuclei were stained.
These results suggest that immunohistochemical detection of p53 oncoprotein can be used as a method for the differentiation between the adenocarcinoma and the adenoma accompanied with severe atypia.
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